Pesquisa sobre:
ARISTOLOCHIC ACIDS
Descritores Encontrados:
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DeCS
Descritor
Inglês
:
Aristolochic Acids
Descritor
Espanhol
:
ácidos aristolóquicos
Descritor
Português
:
Ácidos Aristolóquicos
Categoria:
D02.455.426.559.847.723.089
D02.640.139
D04.615.723.089
Definição
Inglês
:
Nitro-phenanthrenes occurring in
ARISTOLOCHIACEAE
and other
plants
. They derive from stephanine (
APORPHINES
) by oxidative ring cleavage. The nitro group is a reactive alkylator (
ALKYLATING AGENTS
) that binds to biological macromolecules. Ingestion by
humans
is associated with nephropathy (
NEPHRITIS
). There is no relationship to the
similar
named aristolochene (
SESQUITERPENES
).
Nota Histórica
Inglês
:
2003
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Número do Registro:
37310
Identificador Único:
D034341
Ocorrência na BVS
:
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DeCS